The core activity of B'SYS GmbH is to provide services as a Contract Research Organization (CRO) in the field of Ion Channel Discovery for pharmaceutical companies. In particular, the company offers rapid screening services for new substances on ion channel drug targets, including safety services, discovery services, serum shift assays, action potential assays, ion channel trafficking assays, cardiac panel and cardiovascular toxicity tests.
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Industry:Research & DevelopmentPharmaceutical Industry
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Ion channel screening with patch-clamp technology, automated and manual setups, fluorescence screening, and tests on ligand- and voltage-dependent ion channels.
Cell line generation
Stable cell line generation for ion channel targets, including cell line design, validated cell lines, and the CiPA cell line set for research applications.
Safety services
Tests to identify drug interactions with cardiac ion channels and QT prolongation, complemented by central nervous system safety checks.
Discovery services
Ion channel subtype selectivity screens and state-dependency analyses for sodium and calcium channels for lead identification and candidate selection.
GLP testing
GLP-compliant measurements under physiological conditions, including concentration verification of the dose solutions and standardized study procedures.
CiPA screening
Cardiac safety studies based on CiPA and the Comprehensive in Vitro Proarrhythmia Assay for assessing proarrhythmic risks.
Serum Shift Assays
Patch-clamp assays in human plasma to investigate protein binding and its effect on IC50 values and in-vivo effective concentrations.
Action Potential Assays
Assays to measure action potentials in relation to ion channel screening and cardiac safety issues.
Ion Channel Trafficking Assays
Assays to investigate ion channel trafficking in the context of screening and safety applications.
Cardiac Panel
Panel of selected cardiac ion channels and associated test systems for screening and safety studies.
Cardiovascular toxicity
Tests to assess cardiovascular toxicity as part of drug screening and safety pharmacology.
Rare compounds - Low volume applications
Assays and test execution for rare substances and low-volume applications in a screening setting.
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