The company develops and commercializes new medicines, particularly T-cell activated cancer medicines, and provides services in the areas of research and development, clinical trials, pharmacology, toxicology and analytics.
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Antibody-based T-cell engagers for oncology and autoimmune diseases, developed with the M-gager® platform for high tumor selectivity and targeted immune-cell control.
M-gager® platform
Proprietary antibody-fragment platform for developing selective T-cell engagers, with a modular binding architecture, good drug properties and scalable manufacturing.
Oncology programs
Tumor-selective T-cell engagers against solid tumors that are difficult to treat, including CDR404, CDR505, CDR609 and CDR813 for different cancer antigens.
Autoimmunity programs
Targeted therapeutics for autoimmune diseases that address specific immune-cell populations and aim to reset the immune system to a healthy state.
CDR404
Bivalent, bispecific M-gager® against MAGE-A4-positive solid tumors, currently in a Phase 1 study evaluating safety, tolerability and first efficacy.
CDR609
Antibody-based M-gager® against LGR5-expressing solid tumors, developed as a next-generation T-cell engager for selective recruitment of T-cells.
CDR505
Tumor-selective M-gager® against KK-LC-1 on HLA-A*01, designed for common cancers and a patient population that has not yet been addressed.
CDR813
Differentiated M-gager® against PRAME with high potency and specificity to treat cancer cells without targeting normal tissue.
CDR111
T-cell engager against two B-cell targets for effective B-cell depletion, with a potential curative approach in multiple autoimmune diseases.
Partnerships and R&D collaborations
Partnerships with pharmaceutical companies, academic partners and other stakeholders, including joint development and licensing of new targets via the M-gager® platform.