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DirectoryIndustryMedical Technology IndustryZurichCovalX AG
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CovalX AG

Summary

About the company

The core activity of CovalX AG is the development and provision of technologies and services for the analysis of proteins and protein interactions, particularly through mass spectrometry. The focus is on the characterization of therapeutic proteins and providing solutions for the pharmaceutical industry and academic laboratories.

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Offering

Products & services

Industry:Medical Technology Industry
✓ Offered9
Epitope Mapping Service (HDX-MS/XL-MS)
Epitope mapping for antibodies and protein-protein interactions using HDX-MS and XL-MS, including sample QC with High-Mass MALDI MS plus peptide maps, contact maps and an analytical report.
De Novo Sequencing
Reference-free protein and antibody sequencing by MS/MS with multi-enzyme digestion, nano-LC-MS/MS, PTM and glycan profiling, plus QC with High-Mass MALDI MS.
mAb Characterization
Comprehensive antibody characterization with high-resolution LC-MS, intact MALDI-MS, PMF sequence verification, PTM, disulfide, glycan, aggregation and interaction analyses.
Protein Interaction Analysis
Analysis of intact protein complexes with High-Mass MALDI MS and chemical cross-linking to determine complex stoichiometry, binding partners and non-covalent interactions.
Immunoprecipitation Mass Spectrometry (IP-MS)
IP-MS for target identification, mechanism-of-action studies and biomarker discovery, with antibody pulldown, nano-LC-MS/MS, protein interaction lists and an analytical report.
Biophysical Testing
Biophysical characterization of proteins and antibodies with DSC, circular dichroism, FTIR and UV-Vis to assess structure, thermal stability and conformation.
Host Cell Protein Analysis
Host cell protein analysis by mass spectrometry to identify and quantify HCP impurities in biotherapeutics and support purity and quality assessment.
Affinity Analysis (SPR/BLI)
Label-free binding and kinetic analysis with SPR and BLI for lead selection, epitope binning, batch comparison and biosimilarity assessment.
Disulfide Bond Mapping
Disulfide bond analysis for recombinant and purified proteins, with intact mass analysis, peptide mapping, DTT reduction and identification of free or mispaired cysteine residues.
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Location

Mühlebachstrasse 14
8008 Zurich

At a glance

Legal form
Corporation
UID
CHE-112.640.000
Founded
2005 · 21 years
Last commercial register change
October 29, 2025
Employees
21 to 50

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