The core activity of iOnctura is the development of cancer drugs, particularly in oncology immunotherapy, with a focus on solid tumors, uveal melanoma and other types of cancer.
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Oncology small-molecule programs against hard-to-treat, often neglected cancer types; focus on precisely targeted, orally dosed therapeutics with low toxicity.
Roginolisib (IOA-244)
Orally dosed PI3Kδ inhibitor in clinical development for uveal melanoma, NSCLC, myelofibrosis, CLL and PTCL; studied as monotherapy and in combination.
Cambritaxestat (IOA-289)
Orally dosed autotaxin inhibitor in clinical development for pancreatic and liver malignancies; studied in combination with chemotherapy.
IOA-359
Small molecule as a TGF-β signalling pathway inhibitor in development for solid tumors; designed for combination therapies against tumor resistance.
Clinical trials in oncology
Clinical trials in uveal melanoma, pancreatic cancer, NSCLC, myelofibrosis, CLL and PTCL with safety, efficacy and biomarker endpoints.
Precision oncology research
Research on first-in-class mechanisms at the tumor–stroma–immune interface; development of data-driven combination therapies against resistance mechanisms.